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What is a normal HOMA-IR?
There is no single agreed cut-off.
- MDCalc notes that 2.0 to 3.0 is commonly used in the US, and that large US surveys (NHANES) use 2.5 or more.
- Lower cut-offs, from about 1.4, are reported for metabolic problems in Asian populations.
So treat your number as a question for your doctor, not as a diagnosis.
| HOMA-IR | How it is usually read |
|---|---|
| Under 1.4 | Below the lower cut-offs reported in studies |
| 1.4 to 2.5 | The span of cut-offs reported for Asian populations. Read it with your doctor, alongside your other results |
| 2.5 and above | The cut-off used in large US surveys (NHANES) |
Sources: Matthews et al., Homeostasis model assessment, Diabetologia (1985); MDCalc, HOMA-IR: how the number is read.
How this works
HOMA-IR stands for homeostatic model assessment of insulin resistance. It comes from Matthews and colleagues (Diabetologia, 1985): fasting glucose in mg/dL multiplied by fasting insulin in µIU/mL, divided by 405. If your report is in mmol/L, the glucose is multiplied by 18 first, which is the same as dividing by 22.5. It is an estimate from one fasting sample, and it assumes your body makes its own insulin. Labs and studies disagree on where high starts, so your doctor reads it together with your other reports.
A number is a starting point, not a plan. On a free call, Puja looks at it with your reports and your routine.
Questions about your answer?
Once you have an answer, it goes into the message for you, so there is nothing to copy.
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